Can You Take Prednisone on an Empty Stomach?

Prednisone is a commonly prescribed medication that belongs to a class of drugs called corticosteroids. It is used to treat various medical conditions, including inflammation, allergic reactions, and immune system disorders. If you’ve been prescribed prednisone, you might be wondering whether it’s safe to take it on an empty stomach. Let’s explore this topic in detail:

General Guidelines for Taking Prednisone

While prednisone can be taken with or without food, there are certain factors to consider. It’s generally recommended to follow the specific instructions provided by your healthcare provider or the instructions on the medication label. However, here are some general guidelines:

  • With Food: Taking prednisone with food can help reduce the likelihood of stomach upset or irritation. It can also enhance the absorption of the medication, leading to more consistent blood levels.
  • On an Empty Stomach: In some cases, your healthcare provider may recommend taking prednisone on an empty stomach for better absorption. This is especially true for delayed-release formulations or if there are specific reasons related to your condition that require empty stomach administration.

Consult Your Healthcare Provider

It’s important to note that everyone’s medical situation is unique, and the instructions for taking prednisone can vary depending on the individual and the specific condition being treated. Therefore, it’s crucial to consult your healthcare provider for personalized advice.

Possible Side Effects

Regardless of whether you take prednisone on an empty stomach or with food, it’s important to be aware of the potential side effects associated with this medication. Common side effects may include increased appetite, weight gain, mood changes, difficulty sleeping, and increased risk of infections. Long-term use or high doses of prednisone can increase the risk of more severe side effects, such as osteoporosis and adrenal gland suppression. Your healthcare provider can provide detailed information about the potential risks and benefits of prednisone treatment.


Prednisone can be taken on an empty stomach or with food, depending on your healthcare provider’s instructions and the specific formulation of the medication. It’s crucial to follow the prescribed guidelines and consult your healthcare provider if you have any concerns or questions. Prednisone is a powerful medication that can provide significant relief for various medical conditions, but it should be used under the supervision of a healthcare professional to minimize potential risks and optimize its benefits.